Coffee and aspirin may be the most reliable hangover cure, according to a rat study done at Thomas Jefferson University in Philadelphia. The caffeine and aspirin, taken four to six hours after drinking, blocked the effects of the ethanol. (The usual caveats about aspirin, alcohol, and stomach bleeding still apply). 
To tell you the truth, I always take 2 aspirins before I go to a party and 2 more, with a big glass of water, before I go to bed and it helps me – I also try to stand by a 2 drink limit. I hate hangovers. 
Wayne Curtis of the Atlantic has a less rigorous approach: a Bloody Mary. “It contains vodka for the hair of the dog, salt and frutose to aid rehydration and potassium and vitamin C to offset depletions”, he explains. “The high-density ballast of the juice itself settles the stomach. I don’t know about you, but I’m liking this guy.
source: reader’s digest
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